HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome

Epilepsy Behav. 2011 Feb;20(2):390-1. doi: 10.1016/j.yebeh.2010.11.022. Epub 2011 Jan 7.

Abstract

Previous studies have reported that patients with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (PHT-induced SJS/TEN) were positive for HLA-B*1502. We genotyped two patients with PHT-induced SJS using both polymerase chain reaction with sequence-specific primers and sequencing. The results revealed that one patient from Henan Province had HLA-B*1501/B*5401, and the other patient from Guangdong Province had HLA-B*1502/B*4601. When this information was combined with the results from Taiwan and Hong Kong, a significant difference was observed in the presence of HLA-B*1502 between PHT-SJS and PHT-tolerant populations (35% vs 8%, P=0.001, OR=6.08, 95% CI=2.183-16.946). Additional studies in large samples are required to confirm the association between HLA-B*1502 and PHT-induced SJS/TEN.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anticonvulsants / adverse effects*
  • Asian People
  • Genotype
  • HLA-B Antigens / genetics
  • HLA-B35 Antigen
  • Humans
  • Male
  • Phenytoin / adverse effects*
  • Seizures / drug therapy
  • Stevens-Johnson Syndrome / chemically induced*
  • Stevens-Johnson Syndrome / genetics*

Substances

  • Anticonvulsants
  • HLA-B Antigens
  • HLA-B*35:43 antigen
  • HLA-B35 Antigen
  • Phenytoin