4-Deacetylbaccatin III: a proposed biosynthetic precursor of paclitaxel from the bark of Taxus wallichiana

Nat Prod Commun. 2010 Nov;5(11):1727-8.

Abstract

4-Deacetylbaccatin III was isolated and characterized from the bark of Taxus wallichiana Zucc. It was previously identified as an intermediate during the synthesis of paclitaxel and was proposed as a precursor for the biosynthesis of paclitaxel. Existence of 4-deacetylbaccatin III in T. wallichiana is strong evidence for the previously proposed biosynthetic pathway of paclitaxel via 4-deacetylbaccatin III.

MeSH terms

  • Molecular Structure
  • Paclitaxel / biosynthesis*
  • Paclitaxel / chemistry*
  • Plant Bark / chemistry*
  • Taxoids / chemistry*
  • Taxoids / metabolism*
  • Taxus / chemistry*
  • Taxus / metabolism

Substances

  • 4-deacetylbaccatin III
  • Taxoids
  • Paclitaxel