Role of intraoperative imprint cytology in diagnosis of suspected ovarian neoplasms

Asian Pac J Cancer Prev. 2010;11(5):1389-91.

Abstract

Background: The present study was conducted to assess whether cytology can help in rapid diagnosis of ovarian neoplasms and thus facilitate individualised treatment.

Methods: A prospective investigation was performed on 30 cases of suspected ovarian neoplasms. Imprint smears were made intraperatively from fresh samples from various representative areas, and stained with Leishman Giemsa for air-dried smears, and with hematoxylin and eosin and Papanicolaou for alcohol-fixed smears. A rapid opinion regarding the benign or malignant nature of the lesion and the type of tumour was given.

Results: The overall sensitivity was 96.2%, specificity 75%, positive predictive value 96.3%, and diagnostic accuracy of 83.3%. Characteristic cytological patterns were noted in various epithelial and germ cell tumours.

Conclusions: Imprint cytology can be used as an adjunct to histopathology for rapid and early diagnosis in the operation theatre, thus helping better management of patients.

MeSH terms

  • Azure Stains
  • Cytodiagnosis
  • Diagnostic Errors
  • Eosine Yellowish-(YS)
  • Female
  • Hematoxylin
  • Histological Techniques
  • Humans
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Ovary / cytology*
  • Ovary / pathology
  • Staining and Labeling / methods*

Substances

  • Azure Stains
  • Eosine Yellowish-(YS)
  • Hematoxylin