Ocular involvement, mainly as optic neuropathy or retinopathy, in the course of interferon therapy is clinically rare, while the subclinical retinal toxicity is quite frequent. We present a case of retinal toxicity during treatment with PEG-INF alpha 2b and ribavirin for HCV hepatitis. We suggest that all patients receive an ophthalmological examination at base-line and repeated ophthalmological examination only if clinically advisable.