The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution

Chembiochem. 2011 Jan 3;12(1):61-4. doi: 10.1002/cbic.201000564.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Biosynthetic Pathways
  • Evolution, Molecular*
  • Genome, Bacterial / genetics*
  • Genomics / methods*
  • Lactams / metabolism*
  • Micromonosporaceae / genetics*
  • Micromonosporaceae / metabolism*
  • Models, Molecular
  • Molecular Conformation
  • Molecular Sequence Data
  • Peptide Synthases / chemistry
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism
  • Phylogeny

Substances

  • Lactams
  • salinosporamide K
  • Peptide Synthases
  • non-ribosomal peptide synthase