Hepatic and cerebral energy production system in rats with acute and chronic ethanol intoxication

Z V Petrova; D A Korshunov; V A Slepichev; Y G Zyuz'kova; E A Yanovskaya; G A Stykon; V V Udut

doi:10.1007/s10517-010-0909-0

Hepatic and cerebral energy production system in rats with acute and chronic ethanol intoxication

Bull Exp Biol Med. 2010 Aug;149(2):208-12. doi: 10.1007/s10517-010-0909-0.

[Article in English, Russian]

Authors

Z V Petrova¹, D A Korshunov, V A Slepichev, Y G Zyuz'kova, E A Yanovskaya, G A Stykon, V V Udut

Affiliation

¹ Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. zuci@ya.ru

PMID: 21113493
DOI: 10.1007/s10517-010-0909-0

Abstract

We studied the effects of ethanol on the energy production system in the brain and liver in acute and chronic intoxications. Ethanol was found to inhibit mitochondrial respiratory chain in the liver. Acute ethanol intoxication results in uncoupling of oxidative phosphorylation. NAD-dependent respiration prevails in chronic intoxication. In the brain, ethanol exposure induces a compensated low-energy shift with activation of fast mitochondrial metabolic cluster and uncoupling of oxidative phosphorylation.

MeSH terms

Alcoholic Intoxication / metabolism*
Alcoholism / metabolism*
Animals
Brain / drug effects*
Brain / metabolism
Electron Transport / drug effects
Energy Metabolism / drug effects*
Ethanol / toxicity*
Liver / drug effects*
Liver / metabolism
Male
Mitochondria / drug effects*
Mitochondria / metabolism
Oxidative Phosphorylation / drug effects
Oxygen Consumption / drug effects
Rats
Statistics, Nonparametric

Substances

Ethanol