A cationic Zn(II) porphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA

Org Biomol Chem. 2011 Feb 7;9(3):684-8. doi: 10.1039/c0ob00598c. Epub 2010 Nov 25.

Abstract

A water soluble Zn(II) porphyrazine drives the conformational equilibrium of the G-quadruplex of a human telomeric sequence exclusively towards a parallel conformation upon complexation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations / chemistry
  • DNA / chemistry*
  • G-Quadruplexes*
  • Humans
  • Metalloporphyrins / chemistry*
  • Models, Molecular
  • Telomere / chemistry*

Substances

  • Cations
  • Metalloporphyrins
  • tetrakis-2,3-(5,6-di(2-(N-methyl)pyridiniumyl)pyrazino)porphyrazinato-ZnII
  • DNA