3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Int Immunopharmacol. 2011 May;11(5):593-6. doi: 10.1016/j.intimp.2010.11.005. Epub 2010 Nov 24.

Abstract

3G11 is a sialylated carbohydrate epitope of the disialoganglioside molecule expressed on mouse CD4(+) T cells. Recent research showed that 3G11 expression is related to the modulation of T cell function, i.e., 3G11(-) T cells exhibit anergic/Treg characteristics and efficiently inhibit autoimmunity in the central nervous system. The relationship between 3G11 expression and immune tolerance is summarized in this literature review.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Surface / genetics
  • Antigens, Surface / immunology
  • Antigens, Surface / metabolism*
  • Autoimmunity
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism*
  • Central Nervous System / immunology*
  • Epitopes, T-Lymphocyte / metabolism
  • Forkhead Transcription Factors / biosynthesis
  • Gangliosides / metabolism
  • Humans
  • Immune Tolerance*
  • Mice
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism*

Substances

  • Antigens, Surface
  • Epitopes, T-Lymphocyte
  • Forkhead Transcription Factors
  • Foxp3 protein, mouse
  • Gangliosides
  • antigen 3G11, mouse
  • sialogangliosides