NHC-catalyzed intramolecular redox amidation for the synthesis of functionalized lactams

Org Lett. 2010 Dec 17;12(24):5708-11. doi: 10.1021/ol102536s. Epub 2010 Nov 16.

Abstract

A very efficient NHC-catalyzed lactamization reaction is reported. For most cases, the ring expansion reaction proceeds to cleanly furnish five- and six-membered N-Ts and N-Bn lactams, without the need for further purification. Evidence is presented suggesting a dual role for the stoichiometric base: (1) deprotonation of the triazolium precatalyst and (2) activation of the nitrogen leaving group through hydrogen bonding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Catalysis
  • Heterocyclic Compounds / chemistry*
  • Hydrogen / chemistry
  • Lactams / chemical synthesis*
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Heterocyclic Compounds
  • Lactams
  • carbene
  • Hydrogen
  • Methane