Abstract
The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates DNA damage responses at telomeres.
MeSH terms
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Animals
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Cellular Senescence / physiology
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DNA Repair / physiology*
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DNA-Activated Protein Kinase / metabolism
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Humans
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Mice
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Neoplasms / genetics
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Neoplasms / metabolism
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Nuclear Proteins / metabolism
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Proteasome Endopeptidase Complex / metabolism
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Protein Processing, Post-Translational / physiology
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Sister Chromatid Exchange / physiology
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Tankyrases / physiology*
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Telomere / genetics
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Telomere / metabolism*
Substances
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Nuclear Proteins
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Tankyrases
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TNKS protein, human
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DNA-Activated Protein Kinase
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PRKDC protein, human
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Proteasome Endopeptidase Complex