Lower gastrointestinal tract cancer predisposition syndromes

Hematol Oncol Clin North Am. 2010 Dec;24(6):1229-52. doi: 10.1016/j.hoc.2010.08.012.

Abstract

Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Gastrointestinal Neoplasms / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Intestinal Polyposis / congenital
  • Intestinal Polyposis / genetics
  • Mutation*
  • Neoplastic Syndromes, Hereditary
  • Peutz-Jeghers Syndrome / genetics
  • Risk Factors
  • Syndrome

Supplementary concepts

  • Juvenile polyposis syndrome