Abstract
A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC(50) value of 0.92 μM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification*
-
Alkaloids / pharmacology
-
Animals
-
Cerebral Cortex / drug effects
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Huperzia / chemistry*
-
Inhibitory Concentration 50
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Rats
-
Rats, Sprague-Dawley
-
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
-
Synaptic Membranes / drug effects
Substances
-
12-deoxyhuperzine O
-
6-hydroxy-5,15-oxide-lycopodane
-
Alkaloids
-
Drugs, Chinese Herbal
-
Receptors, N-Methyl-D-Aspartate