"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats

Acta Biochim Pol. 2010;57(4):399-402. Epub 2010 Nov 1.

Abstract

Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood Glucose / drug effects*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Disease Models, Animal
  • Geranium / chemistry*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Male
  • Mitochondria, Liver / drug effects*
  • Oxidative Phosphorylation / drug effects
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Rats
  • Rats, Inbred Strains

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Plant Extracts