Abstract
A high-yielding and practical synthesis of the bacterial cell division inhibitor PC190723 is described. The synthesis is completed in a longest linear sequence of five steps from commercially available starting materials and can be readily executed on a multigram scale.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / pharmacology*
-
Bacterial Proteins / chemistry*
-
Bacterial Proteins / metabolism*
-
Cell Division / drug effects
-
Cytoskeletal Proteins / chemistry*
-
Cytoskeletal Proteins / metabolism*
-
Microbial Sensitivity Tests
-
Pyridines / chemical synthesis*
-
Pyridines / chemistry
-
Pyridines / pharmacology*
-
Staphylococcus aureus / chemistry*
-
Staphylococcus aureus / drug effects
-
Staphylococcus aureus / metabolism
-
Thiazoles / chemical synthesis*
-
Thiazoles / chemistry
-
Thiazoles / pharmacology*
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
Cytoskeletal Proteins
-
FtsZ protein, Bacteria
-
PC190723
-
Pyridines
-
Thiazoles