Effect of chronic clonidine treatment on urinary growth hormone excretion and linear growth in children with short stature

Horm Res. 1990;34(5-6):193-6. doi: 10.1159/000181824.

Abstract

Eleven prepubertal children with short stature were treated with clonidine (0.15 mg/m2 daily) for a period of 1 year. The effect of this drug was evaluated on both clinical (growth velocity, height standard deviation scores for chronological age and bone age) and hormonal (urinary growth hormone excretion and insulin-like growth factor I) parameters. Our study shows that long-term clonidine administration in children with short stature did not result in significant differences in growth velocity, height standard deviation scores for chronological age and bone age, insulin-like growth factor I or in urinary growth hormone excretion.

MeSH terms

  • Body Height / drug effects*
  • Child
  • Clonidine / pharmacology*
  • Female
  • Growth Hormone / blood
  • Growth Hormone / drug effects
  • Growth Hormone / urine*
  • Humans
  • Insulin-Like Growth Factor I / drug effects
  • Male

Substances

  • Insulin-Like Growth Factor I
  • Growth Hormone
  • Clonidine