Tripyrrolidinophosphoric acid triamide as an activator in samarium diiodide reductions

Org Lett. 2010 Nov 19;12(22):5178-81. doi: 10.1021/ol102040s. Epub 2010 Oct 27.

Abstract

The electrochemical and spectrophotometric characterization of the complex formed from samarium diiodide and 4 equiv of tripyrrolidinophosphoric acid triamide (TPPA) is presented. Kinetic studies indicate that the SmI(2)/TPPA complex possesses reactivity greater than the complex formed between samarium diiodide and 4 equiv of HMPA. Examples of the use of SmI(2)/TPPA in synthesis are presented.