Association of novelty seeking scores and striatal dopamine D₂/D₃ receptor availability of healthy volunteers: single photon emission computed tomography with ¹²³i-iodobenzamide

J Formos Med Assoc. 2010 Oct;109(10):736-9. doi: 10.1016/S0929-6646(10)60119-2.

Abstract

It has been speculated that novelty seeking (NS) behavior is related to the dopaminergic system. Fifty-two subjects completed the Tridimensional Personality Questionnaire and underwent single photon emission computed tomography with (123)I-iodobenzamide. A marginally positive correlation was noted between NS and striatal dopamine D(2)/D(3) receptor availability (r = 0.25, p =0.07). A positive association was noted between the NS scores and left striatal D(2)/D(3) receptor availability (r= 0.29, p =0.04). The results suggest that a relationship might exist between NS score and dopaminergic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Corpus Striatum / diagnostic imaging
  • Corpus Striatum / metabolism*
  • Exploratory Behavior / physiology*
  • Female
  • Humans
  • Iodobenzenes
  • Male
  • Middle Aged
  • Personality Assessment
  • Personality Inventory
  • Receptors, Dopamine D2 / metabolism*
  • Receptors, Dopamine D3 / metabolism*
  • Surveys and Questionnaires
  • Taiwan
  • Tomography, Emission-Computed, Single-Photon
  • Young Adult

Substances

  • Iodobenzenes
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • idobenzamide