Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation

Intern Med. 2010;49(20):2253-7. doi: 10.2169/internalmedicine.49.3969. Epub 2010 Oct 15.

Abstract

A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Catheter Ablation
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Fatal Outcome
  • Female
  • Hemangiosarcoma / drug therapy
  • Hemangiosarcoma / surgery
  • Hemangiosarcoma / therapy*
  • Hepatectomy
  • Humans
  • Interleukin-3 / therapeutic use
  • Middle Aged
  • Peripheral Blood Stem Cell Transplantation*
  • Prednisone / administration & dosage
  • Recombinant Proteins / therapeutic use
  • Splenectomy*
  • Splenic Neoplasms / drug therapy
  • Splenic Neoplasms / surgery
  • Splenic Neoplasms / therapy*
  • Thrombocytopenia / etiology
  • Vincristine / administration & dosage

Substances

  • Interleukin-3
  • Recombinant Proteins
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • CHOP protocol