Abstract
A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Catheter Ablation
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Fatal Outcome
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Female
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Hemangiosarcoma / drug therapy
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Hemangiosarcoma / surgery
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Hemangiosarcoma / therapy*
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Hepatectomy
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Humans
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Interleukin-3 / therapeutic use
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Middle Aged
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Peripheral Blood Stem Cell Transplantation*
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Prednisone / administration & dosage
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Recombinant Proteins / therapeutic use
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Splenectomy*
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Splenic Neoplasms / drug therapy
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Splenic Neoplasms / surgery
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Splenic Neoplasms / therapy*
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Thrombocytopenia / etiology
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Vincristine / administration & dosage
Substances
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Interleukin-3
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Recombinant Proteins
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone