Polymorphism in exons of the myostatin gene and its relationship with body weight traits in the Bian chicken

Biochem Genet. 2011 Feb;49(1-2):9-19. doi: 10.1007/s10528-010-9380-x. Epub 2010 Oct 8.

Abstract

In our research, single nucleotide polymorphisms (SNPs) of exon regions of the myostatin gene were detected by PCR-SSCP in the Bian chicken and three reference chicken populations (Jinghai, Youxi, and Arbor Acre). Four novel SNPs (G2283A, C7552T, C7638T, and T7661A) were detected. The findings from the least square means showed that Bian chickens with EE and DE genotypes had significantly higher body weight, at 6-18 weeks of age, than those of the DD genotype (P < 0.05). The results suggest that the mutation G2283A, detected in exon 1, has potential as a genetic marker for body weight traits in the Bian chicken.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Population Groups / genetics
  • Animals
  • Body Weight / genetics*
  • Chickens / genetics*
  • Endangered Species
  • Exons / genetics
  • Female
  • Gene Frequency / genetics
  • Genetic Association Studies
  • Genetic Markers
  • Genotype
  • Meat
  • Myostatin* / genetics
  • Phenotype
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide / physiology
  • Polymorphism, Single-Stranded Conformational / physiology
  • Sequence Alignment

Substances

  • Genetic Markers
  • Myostatin