Abstract
An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology
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Drug Resistance, Multiple / drug effects
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Hydrolysis
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Kinetics
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Nitroimidazoles / chemical synthesis*
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Nitroimidazoles / chemistry
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Nitroimidazoles / pharmacology
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Stereoisomerism
Substances
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Antitubercular Agents
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Nitroimidazoles
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pretomanid