Multi-diffusion-tensor fitting via spherical deconvolution: a unifying framework

Med Image Comput Comput Assist Interv. 2010;13(Pt 1):674-81. doi: 10.1007/978-3-642-15705-9_82.

Abstract

In analyzing diffusion magnetic resonance imaging, multi-tensor models address the limitations of the single diffusion tensor in situations of partial voluming and fiber crossings. However, selection of a suitable number of fibers and numerical difficulties in model fitting have limited their practical use. This paper addresses both problems by making spherical deconvolution part of the fitting process: We demonstrate that with an appropriate kernel, the deconvolution provides a reliable approximative fit that is efficiently refined by a subsequent descent-type optimization. Moreover, deciding on the number of fibers based on the orientation distribution function produces favorable results when compared to the traditional F-Test. Our work demonstrates the benefits of unifying previously divergent lines of work in diffusion image analysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Axons / ultrastructure*
  • Brain / ultrastructure*
  • Data Interpretation, Statistical
  • Diffusion Tensor Imaging / methods*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Models, Neurological
  • Nerve Fibers, Myelinated / ultrastructure*
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Statistical Distributions