Hastifolins A-G, antifeedant neo-clerodane diterpenoids from Scutellaria hastifolia

Rosa Angela Raccuglia; Gabriella Bellone; Kristina Loziene; Franco Piozzi; Sergio Rosselli; Antonella Maggio; Maurizio Bruno; Monique S J Simmonds

doi:10.1016/j.phytochem.2010.08.021

Hastifolins A-G, antifeedant neo-clerodane diterpenoids from Scutellaria hastifolia

Phytochemistry. 2010 Dec;71(17-18):2087-91. doi: 10.1016/j.phytochem.2010.08.021. Epub 2010 Sep 25.

Authors

Rosa Angela Raccuglia¹, Gabriella Bellone, Kristina Loziene, Franco Piozzi, Sergio Rosselli, Antonella Maggio, Maurizio Bruno, Monique S J Simmonds

Affiliation

¹ Dipartimento di Chimica Organica, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy.

PMID: 20875654
DOI: 10.1016/j.phytochem.2010.08.021

Abstract

From the aerial parts of Scutellaria hastifolia, family Lamiaceae (Labiatae), seven neo-clerodane diterpenoids (hastifolins A-G) were isolated. The products are similar to the known scuteparvin and are characterized by being trans-cinnamoyl derivatives. Structures and stereochemistry were determined by intensive NMR investigation. Six of the products form three pairs of epimers at C-13. Hastifolins A-C showed significant antifeedant activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diterpenes, Clerodane / chemistry
Diterpenes, Clerodane / isolation & purification
Diterpenes, Clerodane / pharmacology*
Feeding Behavior / drug effects*
Larva / drug effects
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Scutellaria / chemistry*
Spodoptera / drug effects*

Substances

Diterpenes, Clerodane