Fasciola hepatica is a zoonotic liver fluke that can cause disease in humans. F. hepatica is known to cause bile duct inflammation and biliary obstruction, but is rarely reported as responsible for producing acute pancreatitis. We report two patients complaining of acute pancreatitis. Endoscopic retrograde cholangiopancreatography showed distinct features, and sphincterotomy allowed extraction of multiple parasites. A high index of suspicion, specific ultrasonographic findings and eosinophilia are very helpful in the diagnosis of the disease.