Mixed-phenotype acute leukemia relapse in the iris

Yevgeniy Shildkrot; Mihaela Onciu; Mary Ellen Hoehn; Matthew W Wilson

doi:10.1016/j.jaapos.2010.07.007

Mixed-phenotype acute leukemia relapse in the iris

J AAPOS. 2010 Oct;14(5):453-4. doi: 10.1016/j.jaapos.2010.07.007. Epub 2010 Sep 21.

Authors

Yevgeniy Shildkrot¹, Mihaela Onciu, Mary Ellen Hoehn, Matthew W Wilson

Affiliation

¹ University of Tennessee Health Science Center, Department of Ophthalmology, The Hamilton Eye Institute, Memphis, Tennessee 38613, USA.

PMID: 20863726
DOI: 10.1016/j.jaapos.2010.07.007

Abstract

Mixed-phenotype acute leukemia is a rare condition with no previously reported intraocular involvement. We present clinical, radiologic, and cytologic findings of leukemic intraocular relapse in a 23-month-old girl, with lineage switch presenting as conjunctivitis after allogeneic bone marrow transplantation. A diagnostic approach using fine needle aspiration is described.

Publication types

Case Reports

MeSH terms

Acute Disease
Fatal Outcome
Female
Hematopoietic Stem Cell Transplantation*
Humans
Infant
Iris Neoplasms / genetics*
Iris Neoplasms / pathology*
Myeloid-Lymphoid Leukemia Protein / genetics
Oncogene Proteins, Fusion / genetics
Phenotype
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / pathology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / therapy
Recurrence
Translocation, Genetic

Substances

MLL-AF10 fusion protein, human
Oncogene Proteins, Fusion
Myeloid-Lymphoid Leukemia Protein