Background: To explore the relationship between the apoptotic level of lung cancer cell and oncogenesis , development and prognosis of lung cancer.
Methods: The apoptotic level of lung cancer cell was detected in 124 non2small cell lung cancer samples , and their normal lung tissues adjacent to cancer and 40 normal pulmonary tissues as control by TUNEL.
Results: (1) The apoptotic index (AI) in the lung cancer tissues was significantly lower than that in the normal tissues adjacent to lung cancer and normal lung tissues ( P < 0. 01) ; (2) The AI of lung cancer cell was closely related to P2TNM stages , lymph node involvement of the cancer ( P < 0. 05) ,but no close relation was observed among the AI , histological classification , cancer differentiation , size of the primary tumor , site of the cancer , age , sex of patients and smoking or not ( P > 0. 05) ; (3) The 52year survival rate (45. 57 %) of patients in high AI group was significantly higher than that (14. 69 %) in lower AI group ( P < 0. 01) .
Conclusions: Apoptotic suppression of lung cancer cells may play an important role in the oncogenesis , development and prognosis of lung cancer. Detection of apoptosis of lung cancer cells might be helpful to predict prognosis and guide the postoperative treatment in patients with lung cancer.