Evaluation of antibacterial soap in the management of lymphoedema in Leogane, Haiti

Trans R Soc Trop Med Hyg. 2011 Jan;105(1):58-60. doi: 10.1016/j.trstmh.2010.08.011. Epub 2010 Sep 17.

Abstract

In areas endemic for lymphatic filariasis, progression of lymphoedema is associated with recurrent bacterial acute dermatolymphangioadenitis (ADLA). The role of antibacterial soap in preventing ADLA is unknown. In a randomized double-blinded clinical trial in Leogane, Haiti, lymphoedema patients washed affected legs with antibacterial (n = 97) or plain soap (n = 100). Reported ADLA incidence (by recall) before the study was 1.1 episodes per person-year, compared to 0.40 assessed during the 12-month study. ADLA incidence was significantly associated with age, illiteracy and lymphoedema stage, but not with soap type. Washing with soap, regardless of its antibacterial content, can help decrease ADLA incidence. (ClinicalTrials.gov identifier number NCT00139100.).

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Elephantiasis, Filarial / complications
  • Elephantiasis, Filarial / epidemiology
  • Elephantiasis, Filarial / prevention & control*
  • Female
  • Haiti / epidemiology
  • Humans
  • Lymphedema / epidemiology
  • Lymphedema / etiology
  • Lymphedema / prevention & control*
  • Male
  • Soaps / therapeutic use*

Substances

  • Anti-Bacterial Agents
  • Soaps

Associated data

  • ClinicalTrials.gov/NCT00139100