Abstract
The therapeutic options available for central nervous system (CNS) infections due to resistant Gram-positive cocci remain limited. We report an unusual case of community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction in the middle cerebral artery territory in a previously healthy young male. After an initial vancomycin-based regimen, treatment was completed with a seven-week course of linezolid and levofloxacin. The potential role of such a combination and, particularly, linezolid as a first-line therapy in serious CNS infections is also discussed.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / administration & dosage*
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Adult
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Anti-Bacterial Agents / administration & dosage
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Cerebral Infarction / complications
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Cerebral Infarction / diagnosis
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Cerebral Infarction / drug therapy*
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Community-Acquired Infections / complications
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Community-Acquired Infections / diagnosis
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Community-Acquired Infections / drug therapy
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Drug Therapy, Combination
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Humans
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Levofloxacin*
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Linezolid
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Male
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Meningitis, Bacterial / complications
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Meningitis, Bacterial / diagnosis
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Meningitis, Bacterial / drug therapy*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification*
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Ofloxacin / administration & dosage*
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Oxazolidinones / administration & dosage*
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Staphylococcal Infections / complications
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Staphylococcal Infections / diagnosis
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Staphylococcal Infections / drug therapy*
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Levofloxacin
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Ofloxacin
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Linezolid