[Percutaneous administration of recombinant human bone morphogenetic protein-7 (rhBMP-7) after callus distraction. Two case reports]

Unfallchirurg. 2011 Feb;114(2):167-71. doi: 10.1007/s00113-010-1815-7.
[Article in German]

Abstract

Two cases of increased bone density after callus distraction are described following percutaneous administration of 3.5 mg recombinant bone morphogenetic protein-7 (rhBMP-7). Both patients underwent segmental resection and segmental transport for osteomyelitis of the long bones (femur and tibia) but no callus maturation occurred. After percutaneous administration of rhBMP-7 the callus density increased in both cases.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Administration, Topical
  • Adult
  • Bone Morphogenetic Protein 7 / administration & dosage*
  • Bony Callus / drug effects*
  • Fracture Healing / drug effects*
  • Humans
  • Intercellular Signaling Peptides and Proteins / administration & dosage
  • Male
  • Osteitis / complications
  • Osteitis / drug therapy*
  • Osteitis / surgery*
  • Osteogenesis, Distraction*
  • Treatment Outcome
  • Young Adult

Substances

  • BMP7 protein, human
  • Bone Morphogenetic Protein 7
  • Intercellular Signaling Peptides and Proteins