Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Org Lett. 2010 Oct 1;12(19):4217-9. doi: 10.1021/ol101568d.

Abstract

1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Hydroxides / chemistry
  • Molecular Structure
  • Transition Elements / chemistry
  • Triazoles / chemical synthesis*

Substances

  • Hydroxides
  • Transition Elements
  • Triazoles