Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form

Chem Commun (Camb). 2010 Oct 14;46(38):7187-9. doi: 10.1039/c0cc02049d. Epub 2010 Aug 27.

Abstract

Herein we report that Aβ aggregates, not Aβ monomer, can convert Z-DNA back to B-form, and curcumin, a well-known Aβ aggregation inhibitor, can stop DNA Z-B transition studied by means of biophysical and biochemical methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Curcumin / pharmacology
  • DNA, Z-Form / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Models, Molecular
  • Protein Multimerization

Substances

  • Amyloid beta-Peptides
  • DNA, Z-Form
  • Enzyme Inhibitors
  • Curcumin