Additive effect of epithelial denudation and low levels of inflammatory mediators on the sensitivity of isolated human airways to methacholine

R C Jongejan; J C de Jongste; H C Raatgeep; I L Bonta; K F Kerrebijn

doi:10.1007/978-3-0348-7379-6_38

Additive effect of epithelial denudation and low levels of inflammatory mediators on the sensitivity of isolated human airways to methacholine

Agents Actions Suppl. 1990:31:279-82. doi: 10.1007/978-3-0348-7379-6_38.

Authors

R C Jongejan¹, J C de Jongste, H C Raatgeep, I L Bonta, K F Kerrebijn

Affiliation

¹ Department of Pediatrics, Erasmus University/Sophia Children's Hospital, Rotterdam, The Netherlands.

PMID: 2080761
DOI: 10.1007/978-3-0348-7379-6_38

Abstract

The presence of low concentrations of histamine or the stable thromboxane analogue U46619 and the removal of the epithelium separately and addictively increase the sensitivity of isolated human airways to methacholine. This raises the possibility that these factors play a role in the pathogenesis of bronchial hyperresponsiveness to inhaled methacholine in asthma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Bronchi / drug effects
Bronchi / physiology*
Dose-Response Relationship, Drug
Epithelium / physiology
Histamine / pharmacology*
Histological Techniques
Humans
In Vitro Techniques
Methacholine Chloride / pharmacology*
Osmolar Concentration
Prostaglandin Endoperoxides, Synthetic / pharmacology*

Substances

Prostaglandin Endoperoxides, Synthetic
Methacholine Chloride
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Histamine