Abstract
We report in this Communication a facile, two-step surface modification strategy to achieve manganese oxide nanoparticles with prominent MRI T1 contrast. In a U87MG glioblastoma xenograft model, we confirmed that the particles can accumulate efficiently in tumor area to induce effective T1 signal alteration.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Contrast Media / chemistry*
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Copper Radioisotopes
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Humans
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Magnetic Resonance Imaging*
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Manganese Compounds / chemistry*
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / ultrastructure
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Mice
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Neoplasms, Experimental / diagnosis*
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Neoplasms, Experimental / diagnostic imaging
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Oxides / chemistry*
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Positron-Emission Tomography
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Serum Albumin / chemistry*
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Transplantation, Heterologous
Substances
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Contrast Media
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Copper Radioisotopes
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Manganese Compounds
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Oxides
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Serum Albumin
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manganese oxide