The Immunoproteasome Cleans up after Inflammation

Sjoerd van Deventer; Jacques Neefjes

doi:10.1016/j.cell.2010.08.002

The Immunoproteasome Cleans up after Inflammation

Cell. 2010 Aug 20;142(4):517-8. doi: 10.1016/j.cell.2010.08.002.

Authors

Sjoerd van Deventer¹, Jacques Neefjes

Affiliation

¹ The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

PMID: 20723753
DOI: 10.1016/j.cell.2010.08.002

Abstract

Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse models of inflammatory disease that immunoproteasomes help prevent the accumulation of harmful protein aggregates.

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