Pd(II)-catalyzed hydroxyl-directed C-H activation/C-O cyclization: expedient construction of dihydrobenzofurans

Xisheng Wang; Yi Lu; Hui-Xiong Dai; Jin-Quan Yu

doi:10.1021/ja105366u

Pd(II)-catalyzed hydroxyl-directed C-H activation/C-O cyclization: expedient construction of dihydrobenzofurans

J Am Chem Soc. 2010 Sep 8;132(35):12203-5. doi: 10.1021/ja105366u.

Authors

Xisheng Wang¹, Yi Lu, Hui-Xiong Dai, Jin-Quan Yu

Affiliation

¹ Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

PMID: 20715820
DOI: 10.1021/ja105366u

Abstract

A Pd(II)-catalyzed C-H activation/C-O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Benzofurans / chemical synthesis*
Benzofurans / chemistry
Catalysis
Cyclization
Hydroxides / chemistry*
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*
Stereoisomerism

Substances

Benzofurans
Hydroxides
Organometallic Compounds
Palladium
hydroxide ion