Abstract
Low concentrations of TGF-beta inhibited the clonal proliferation of three different preparations of mouse bone marrow progenitor cells in vitro. Normal marrow cells responsive to CSF-1; two-day post-fluorouracil cells responsive to CSF-1 plus IL-3 and IL-1 alpha; and regenerating seven-day post-fluorouracil cells responsive to CSF-1 plus IL-3, IL-1 alpha and IL-6 were all severely inhibited by TGF-beta 1; and the inhibitory effects were antagonized by increasing the concentrations of the relevant growth factors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bone Marrow Cells*
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Cell Division / drug effects
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Cells, Cultured
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Dose-Response Relationship, Drug
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Growth Substances / pharmacology*
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / drug effects
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Interleukin-1 / pharmacology
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Interleukin-3 / pharmacology
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Interleukin-6 / pharmacology
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Macrophage Colony-Stimulating Factor / pharmacology
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Male
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Mice
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Mice, Inbred CBA
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Recombinant Proteins / pharmacology
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Transforming Growth Factor beta / antagonists & inhibitors
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Transforming Growth Factor beta / pharmacology*
Substances
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Growth Substances
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Interleukin-1
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Interleukin-3
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Interleukin-6
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Recombinant Proteins
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Transforming Growth Factor beta
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Macrophage Colony-Stimulating Factor