Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica

J Nat Prod. 2010 Aug 27;73(8):1448-52. doi: 10.1021/np100325q.

Abstract

Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology*
  • Azadirachta / chemistry*
  • Burkina Faso
  • Fruit / chemistry
  • Limonins / chemistry
  • Limonins / pharmacology
  • Plants, Medicinal / chemistry*
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • Antimalarials
  • Limonins
  • Triterpenes
  • azadirone
  • neemfruitin A
  • neemfruitin B
  • gedunin