Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques

W Van Hul; H Backhovens; G Van Camp; P Stinissen; M Cruts; A Wehnert; C Van Broeckhoven

doi:10.1007/BF00204162

Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques

Hum Genet. 1991 Jun;87(2):109-11. doi: 10.1007/BF00204162.

Authors

W Van Hul¹, H Backhovens, G Van Camp, P Stinissen, M Cruts, A Wehnert, C Van Broeckhoven

Affiliation

¹ Department of Biochemistry, Born-Bunge Foundation, University of Antwerp (UIA), Belgium.

PMID: 2066096
DOI: 10.1007/BF00204162

Abstract

We were able to refine the chromosomal position of two existing marker loci, using an extended chromosome 21 somatic cell hybrid panel. The locus D21S26 mapped in the region 21q11.2-q21.1, and the locus D21S24 in 21q22.1-q22.2. Physical and genetic analysis indicated that D21S26 is tightly linked to D21S13 and D21S16, two markers previously linked to familial Alzheimer's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / genetics
Blotting, Southern
Cell Line
Chromosome Mapping*
Chromosomes, Human, Pair 21*
Genetic Linkage
Genetic Markers
Humans
In Vitro Techniques

Substances

Genetic Markers