First detection of oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Morocco

Ann Trop Med Parasitol. 2010 Jun;104(4):327-30. doi: 10.1179/136485910X12743554760108.

Abstract

The frequency of carbapenem resistance due to class-D beta-lactamases (i.e. oxacillinases) among the world's Enterobacteriaceae is increasing. Recently, in Morocco, two isolates of carbapenem-resistant Klebsiella pneumoniae were recovered from the same patient, one harbouring plasmid-encoded bla-(OXA-48) and the other the bla-(OXA-1) gene. This represents the first evidence of bla(OXA-48)-mediated carbapenem-resistance in Enterobacteriaceae in Morocco.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Carbapenems / therapeutic use*
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • Klebsiella Infections / drug therapy*
  • Klebsiella Infections / enzymology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology
  • Male
  • Middle Aged
  • Morocco
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • beta-Lactamases
  • oxacillinase