Cell migration: MIM takes the driver's seat

Curr Biol. 2010 Jul 27;20(14):R606-8. doi: 10.1016/j.cub.2010.05.045.

Abstract

A recent study reports a novel and conserved function for the I-BAR protein MIM in guiding cell migration: MIM has an anti-endocytic activity that moderates intracellular signalling of guidance cues by sequestration of cortactin.

MeSH terms

  • Animals
  • Cell Movement / physiology*
  • Cortactin / metabolism
  • Drosophila / embryology*
  • Drosophila / physiology*
  • Drosophila Proteins / metabolism*
  • Microfilament Proteins / metabolism*
  • Models, Biological*
  • Signal Transduction / physiology*

Substances

  • Cortactin
  • Drosophila Proteins
  • MIM protein, Drosophila
  • Microfilament Proteins