Genotype variation of Trypanosoma cruzi isolates from different Brazilian biomes

Exp Parasitol. 2011 Jan;127(1):308-12. doi: 10.1016/j.exppara.2010.07.013. Epub 2010 Jul 23.

Abstract

Chagas disease is an enzootic disease, in which the flagellate Trypanosoma cruzi infects a large variety of animals. Humans are accidentally infected due to the migration into wild environments. To identify T. cruzi discrete typing units (DTUs), 19 Brazilian isolates from different biomes and hosts were analyzed by PCR amplification of 24Sα rRNA, 18S rRNA and mini-exon gene sequences. The majority of the isolates was classified as TcIIb (TcII) but subtypes TcIIc (TcIII) and TcIId (TcV) were also identified. In addition, in monkeys TcI was detected.

MeSH terms

  • Animals
  • Brazil
  • Chagas Disease / parasitology*
  • Didelphis / parasitology
  • Exons / genetics
  • Genotype
  • Humans
  • Leontopithecus / parasitology
  • Polymerase Chain Reaction
  • Primate Diseases / parasitology
  • Primates
  • RNA, Ribosomal / genetics
  • Rodent Diseases / parasitology
  • Rodentia
  • Triatominae / parasitology
  • Trypanosoma cruzi / classification*
  • Trypanosoma cruzi / genetics

Substances

  • RNA, Ribosomal