Objective: To investigate the expressions of extracellular matrix metalloproteinase inducer (CD147), matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9) in human laryngeal carcinoma and study their relationship with invasion, metastasis and prognosis.
Methods: The EnVision immunohistochemical method was used to detect the expressions of CD147, MMP-2 and MMP-9 in 48 cases of laryngeal carcinoma and 15 cases of laryngitis. The results were compared with their clinical pathological features and prognosis.
Results: The positive expression rates of CD147, MMP-2 and MMP-9 were significantly higher in laryngeal carcinoma than those in laryngitis (87.5%, 75.0%, 79.2% vs 26.7%, 6.7%, 33.3%); there was a positive correlation between a high-level expression of CD147, MMP-2, MMP-9 and clinical stage and the status of lymph node metastasis (P < 0.01); univariate analysis indicated that the overall survival rate was higher in patients with a negative expression of CD147, MMP-2, MMP-9 than those with a positive expression (83.3%, 83.3%, 90.0% vs 25.0%, 7.7%, 18.2%); multivariate analysis showed that MMP-9 was a risk predictor. A higher expression of MMP-9 was associated with a shorter survival time.
Conclusion: CD147 and MMP-2 play a role in invasion and metastasis of laryngeal carcinoma; increased levels of MMP-2 and MMP-9 are induced by CD147 in laryngeal tumor cells; MMP-9 may be an independent prognostic factor.