Constructing multiply substituted arenes using sequential palladium(II)-catalyzed C-H olefination

Angew Chem Int Ed Engl. 2010 Aug 16;49(35):6169-73. doi: 10.1002/anie.201002077.

Abstract

Complementary catalytic systems have been developed in which the reactivity/selectivity balance in Pd(II)-catalyzed ortho-C–H olefination can be modulated through ligand control. This allows for sequential C–H functionalization for the rapid preparation of 1,2,3-trisubstituted arenes. Additionally, a rare example of iterative C–H activation, in which a newly installed functional group directs subsequent C–H activation has been demonstrated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkenes / chemical synthesis
  • Alkenes / chemistry*
  • Carbon / chemistry
  • Catalysis
  • Hydrogen / chemistry
  • Palladium / chemistry*
  • Styrene / chemistry

Substances

  • Alkenes
  • Styrene
  • Palladium
  • Carbon
  • Hydrogen