Prospective analysis of the results of clinic-laboratory investigations in patients, treated for Barrett's esophagus (BE) in 2000 - 2006 yrs, was conducted. In some of the patients BE was diagnosed together with other complications of gastroesophageal reflux disease. Statistical analysis of remote results concerning the patients surgical and conservative treatment, using mathematic method, according to the rule 3s and 3s(1), was performed. Higher efficacy of surgical method was established concerning the treatment of hiatal hernia, shortened esophagus, reflux-esophagitis, gastroesophageal and duodenogastric refluxes, duodenal ulcer and esophageal epithelium dysplasia.