Epidural analgesia is the gold standard for the management of pain after thoracopulmonary surgery. However, it is not without side-effects and complications. We report the case of a 52-year-old man who underwent left lower lobectomy for a carcinoid tumor. He received multimodal anesthesia combining epidural thoracic anesthesia and balanced intravenous general anesthesia. He presented with pneumocephalus on the 10th postoperative day. Etiological assessment consisted of isotopic cisternography and cerebromedullar magnetic resonance imaging (MRI), revealing a breach in the fourth left spinal dural nerve sheath. Although it was initially suspected, the thoracic epidural was eventually excluded as the cause. Management consisted of prompt surgical repair.