Abstract
Two new oxygenated sterols, 3β,24(S)-dihydroxycholesta-5,25-dien-7-one and 3β,25-dihydroxycholesta-5,23-dien-7-one, were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC₅₀ values between 22.58 and 53.41 µg mL⁻¹.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / isolation & purification
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Antineoplastic Agents* / pharmacology
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Bryozoa / chemistry*
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Cell Line, Tumor
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Cholestenones
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Cytostatic Agents* / chemistry
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Cytostatic Agents* / isolation & purification
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Cytostatic Agents* / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy / methods
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Sterols* / chemistry
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Sterols* / isolation & purification
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Sterols* / pharmacology
Substances
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3beta,24(S)-dihydroxycholesta-5,25-dien-7-one
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3beta,25-dihydroxycholesta-5,23-dien-7-one
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Antineoplastic Agents
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Cholestenones
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Cytostatic Agents
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Sterols