The projection approximation and edge contrast for x-ray propagation-based phase contrast imaging of a cylindrical edge

Opt Express. 2010 May 10;18(10):9865-78. doi: 10.1364/OE.18.009865.

Abstract

We examine the projection approximation in the context of propagation-based phase contrast imaging using hard x-rays. Specifically, we consider the case of a cylinder or a rounded edge, as a simple model for the edges of many biological samples. The Argand-plane signature of a propagation-based phase contrast fringe from the edge of a cylinder is studied, and the evolution of this signature with propagation. This, along with experimental images obtained using a synchrotron source, reveals how propagation within the scattering volume is not fully described in the projection approximation's ray-based approach. This means that phase contrast fringes are underestimated by the projection approximation at a short object-to-detector propagation distance, namely a distance comparable to the free-space propagation within the volume. This failure of the projection approximation may become non-negligible in the detailed study of small anatomical features deep within a large body. Nevertheless, the projection approximation matches the exact solution for a larger propagation distance typical of those used in biomedical phase contrast imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Microscopy, Phase-Contrast / methods*
  • Models, Biological*
  • Radiographic Image Interpretation, Computer-Assisted / methods*
  • Radiography / methods*
  • Scattering, Radiation