The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids

Fertil Steril. 2010 Dec;94(7):2783-5. doi: 10.1016/j.fertnstert.2010.05.034. Epub 2010 Jul 1.

Abstract

The cytochrome P-450 1A1 (CYPA1A) gene plays an important role in the metabolization of estrogen and is therefore a candidate marker for fibroids. In a case-control study, we were unable to demonstrate any association between MSP I CYP1A1 polymorphism and the risk of leiomyoma in Brazilian women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brazil
  • Case-Control Studies
  • Cytochrome P-450 CYP1A1 / genetics*
  • Cytochrome P-450 CYP1A1 / physiology
  • Deoxyribonuclease HpaII* / metabolism
  • Estradiol / blood
  • Estradiol / pharmacokinetics
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Leiomyoma / blood
  • Leiomyoma / genetics*
  • Leiomyoma / metabolism
  • Metabolic Clearance Rate / genetics
  • Middle Aged
  • Polymorphism, Restriction Fragment Length / genetics
  • Polymorphism, Restriction Fragment Length / physiology*
  • Risk Factors
  • Uterine Neoplasms / blood
  • Uterine Neoplasms / genetics*
  • Uterine Neoplasms / metabolism

Substances

  • Estradiol
  • Cytochrome P-450 CYP1A1
  • Deoxyribonuclease HpaII