Clinical study on mesothelioma in Japan: Relevance to occupational asbestos exposure

Am J Ind Med. 2010 Nov;53(11):1081-7. doi: 10.1002/ajim.20868.

Abstract

Background: In 2003, the number of deaths due to malignant mesothelioma in Japan was 878; however, only 85 cases of mesothelioma due to asbestos exposure were authorized for compensation. The reasons for this discrepancy require evaluation.

Method: We examined medical records, X-rays, and pathology results to evaluate mesothelioma cases in Japan between 2003 and 2005; used a questionnaire to identify occupational and environmental histories, and determined the concentration of asbestos fibers in pathology specimens.

Results: We identified 442 definite cases of malignant mesothelioma with a median age of 68 years. There were 316 malignant mesothelioma cases with occupational asbestos exposure, 12 cases with neighborhood exposure and 5 cases with likely domestic exposure. Most (78%) of the 87 cases exceeded 1,000 asbestos particles per gram of dry lung tissue.

Conclusion: We conclude that 79.2% of cases of mesothelioma in Japan in recent years were caused by asbestos exposure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asbestos / toxicity*
  • Chi-Square Distribution
  • Female
  • Humans
  • Japan / epidemiology
  • Kaplan-Meier Estimate
  • Male
  • Medical Records
  • Mesothelioma / classification
  • Mesothelioma / diagnosis
  • Mesothelioma / etiology*
  • Mesothelioma / mortality
  • Middle Aged
  • Neoplasms / classification
  • Neoplasms / diagnosis
  • Neoplasms / etiology*
  • Neoplasms / mortality
  • Occupational Exposure / adverse effects*
  • Retrospective Studies
  • Surveys and Questionnaires
  • Workers' Compensation
  • Young Adult

Substances

  • Asbestos