The study aimed at the evaluation of clinical efficacy and safety of the neurotrophic medication omaron, a combination of piracetam and cinnarizin, in the early restoration period of ischemic stroke. One hundred and twenty post stroke patients were examined. A diagnosis was confirmed by the brain MRI and CT examination. Neurological and mental status of patients was assessed with a number of scales. The omaron therapy reduced significantly the neurological deficit and improved health status and functioning of patients. The drug was well-tolerated by patients.