A 78-year-old patient underwent diode cyclophotocoagulation for end-stage pseudoexfoliation glaucoma after many surgical interventions on the only functional eye. On the first post-operative day the eye showed a mild flare and the intraocular eye pressure was normal. Nevertheless the patient complained of a severe decrease of visual acuity. A subluxation of a retropupillary iris claw intraocular lens within an atrophic area of the iris was found. During surgical revision the iris claw lens was successfully repositioned in the posterior chamber and an enclavation was performed at a different location avoiding atrophic areas of the iris. Fixation of an iris claw lens onto an atrophic iris structure should be avoided. Subluxation of an iris claw lens can occur following an uncomplicated diode laser cyclophotocoagulation operation.